Construction of circRNA-miRNA-mRNA Network Involved in Pituitary Adenoma using High-Throughput Sequencing and Bioinformatics Analysis

We conducted a study to identify circular RNAs associated with invasive non-functioning pituitary adenomas and chemoresistance, as well construct competitive endogenous RNA network. performed expression profiling of 10 specimens using sequencing identified 37 differentially expressed RNAs, which were validated real-time quantitative polymerase chain reaction. also detected 26 microRNAs 388 messenger microarray profiles downloaded from GSE191113. predicted the interaction among constructed RNA-microRNA-messenger regulatory Our comprehensive bioinformatic analysis revealed pathways PA invasion chemoresistance. Enrichment their association drug resistance. established protein-protein network four hub genes (suppressor cytokine signaling 3, leptin receptor, interleukin 6 receptor protein tyrosine phosphatase receptor-type C). Overall, our provides valuable insights into drug-resistance nature could be useful in identifying potential biomarkers or therapeutic targets for